Gano Cordyceps – Mecanismul de actiune si tratament+Studii
Posted in Despre Ganoderma on 06/27/2009 12:03 am by rekcah89Cordyceps
Pe pasunile de pe platourile Tibetului, aflate la altitudini cuprinse intre 3.500 – 6.000 m deasupra nivelului marii, creste o planta ciudata si fascinanta. Cordiceps, care este folosita in terapeutica chineza de cca. 1.200 ani. Aceasta planta, catalogata de botanisti in clasa ciupercilor, dispune de calitati duble: intr-o parte a ciclului sau biologic este planta, in alta parte a ciclului este insecta.
Cand Cordicepsul exista sub forma de planta, vara, in perioada formarii de spori, sporul plantei este imprastiat de vant , si paraziteaza larva unui fluture, trecand din ciclul vegetal in cel animal. Larva infectata se ingroapa in pamant in forma de gogoasa. Cordicepsul hiberneaza pe timpul iernii, hranindu-se din gogoasa fluturelui, apoi din radacinile unor plante , rezistand astfel sub pamant timp indelungat.
Cand conditiile climatice sunt favorabile, rasare din pamant o noua planta , si ciclul biologic se reia. Aceasta planta impreuna cu ginsengul, cornitele pufoase de cerb, face parte din cele trei mari medicamente tonifiante ale Chinei. Suplimentul biologic activ “Cordiceps” al firmei Tianshi, este obtinut din miceliu ( corpul ) ciupercii Cordiceps-ului chinez natural, fiind denumit si “Aurul medicamentelor”
Mecanismul de actiune si de tratament:
- Efect inalt de reglare a imunitatii ( imunoregulator )
- Echilibreaza functiile Yin-Yang ale organismului
- Este un antibiotic natural, avand actiune bacteriostatica asupra majoritatii bacteriilor ( pneumococi, streptococi, stafilococul auriu ), virusi, agenti patogeni
- Efect antiinflamator, care este egal sau mai mare cu al hidrocortizonului
- Actiune anticancerigena, imbunatatind starea organului afectat, cit si stimularea activitatii leucocitelor, ce reduce actiunea nociva a radioterapiei
- Dilatarea lenta si indelungata a vaselor sanguine,ce permite imbunatatirea aprovizionarii cu singe a muschilor cardiaci si a altor organe, care preintimpina aparitia unor boli grave: tromboze, infarctul miocardic, ischemie cardiaca, boli ale ficatului, rinichilor, plamanilor, etc
- Mareste rezistenta organismului la insuficienta de oxigen, combate oboseala si creste capacitatea de munca
- Are efect antioxidant
- Reduce nivelul lipidelor in organism si a colesterolului, regleaza nivelul calciului si a fosforului in singe
- Eliminarea din organism a substantelor toxice, inclusiv a substantelor nocive din medicamente
- Regleaza functia ficatului, rinichilor, plaminilor si mareste schimburile in tesutul organelor (elimina toxinele, reface celulele afectate, distruge virusii din celulele hepatice )
- Regleaza nivelul trombocitelor in singe
INDICATIILE TERAPEUTICE
- Boli ale organelor respiratorii : bronsita, pneumonie, astm bronsic, emfizem pulmonar, tuberculoza, etc
- Boli ale aparatului cardiovascular si ale vaselor de singe : ischemie cardiaca, infarctul de miocard, stenocardie,tromboze
- Boli ale cailor urinare: colici renale, urinari dese, polutie (eliminarea spontana a spermei ),afectarea calitatii urinei, pielonefrita, glomerulonefrita, cistita, dializa renala ( doza se stabileste de medic ), etc
- Tumori maligne ale diferitelor organe, chiar in stadii avansate ( imbunatatirea functiilor organului afectat, suprimarea principalului focar al tumorii ), inlatura efectele negative ale chimioterapiei si radioterapiei
- Boli ale ficatului : hepatita, profilaxia cirozei hepatice, imbunatateste schimburile in celulele ficatului ( hepatocistite )
- Boli ale singelui : hemoragii ale mucoaselor, purpura trombocitopenica (boala Verlgof ), anemii, leucoze, stabilizeaza evolutia
- Intoxicatii chimice : eliminarea substantelor toxice, toxine intestinale, efectele nocive ale medicamentelor si radionucleidelor,
- Efect curativ si tratament profilactic pentru intarirea imunitatii
- Reduce reactia de respingere de care organism a unor organe noi
( transplant de organe )
Recomandari :
Boli ale organelor respiratorii : bronsita, pneumonie, astm bronsic, emfizem pulmonar, tuberculoza, etc;
Boli ale aparatului cardiovascular si ale vaselor de singe : ischemie cardiaca, infarctul de miocard, stenocardie,tromboze;
Boli ale cailor urinare: colici renale, urinari dese, polutie (eliminarea spontana a spermei ) glomerulonefrita, cistita, etc;
Tumori maligne ale diferitelor organe, chiar in stadii avansate ( imbunatatirea simtitoare a functiilor organului afectat), contribuie la diminuarea efectelor negative ale chimioterapiei si radioterapiei;
Boli ale ficatului : hepatita, profilaxia cirozei hepatice, imbunatateste schimburile in celulele ficatului (hepatocistite);
Boli ale singelui : hemoragii ale mucoaselor, purpura trombocitopenica (boala Verlgof ), anemii, leucoze;
Intoxicatii chimice : ajuta la eliminarea substantelor toxice, toxinelor intestinale, efectelor nocive ale medicamentelor de sinteza; – Efect curativ si tratament profilactic pentru intarirea imunitatii;
Impotenta manifestata prin: lipsa de stamina, lipsa de anduranta, ejaculare precoce.
60 Capsule
Administrare :
Pe stomacul gol sau inainte de masa , cate 1-2 capsule de 1-2 ori pe zi cu un pahar de apa calduta timp de 1 saptamana, 1 saptamana pauza, cu reluarea ciclurilor pina la terminarea flaconului ( se recomanda a se lua dimineata intre orele 9-11);
- In cazul infectiilor, la recomandarea medicului, doza se poate mari pana la 6 – 8 capsule / zi ( 2 capsule la 6 ore ), iar in cazul infectiilor sangelui , medicii chinezi recomanda 6 capsule de 3 ori pe zi;
- Pentru eliminarea efectelor nocive ale chimioterapiei, se recomanda : 8 – 10 capsule / zi; – Profilactic , se recomanda 1 capsula / zi – 3 flacoane pe an;
- La copii, se recomanda numai pe perioada imbolnavirilor;
- 4-5 capsule simultan administrate cu 30 min. – 1 ora inainte de actul sexual au ca efect o anduranta si o dinamica marita a actului sexual, insotita si de unele efecte afrodisiace.
Nu are efecte nedorite asupra inimii. In unele cazuri poate induce o usoara durere de cap.
Indicatii :
Suport pentru: circulatia sanguina, functia hepatica, functia pulmonara; energizant activitate intelectuala; bacteriostatic pentru: pneumococ, streptococ, stafilococ (aureus);
Pentru virilitate: 4-5 capsule administrate cu 30 minute-1 ora inainte de actul sexual au ca efect un act sexual dinamic si de durata.
Suport pentru functia hepatica (ficat) si sistemul nervos, mareste eliberarea de energie la nivel celular, mareste gradul de utilizare al oxigenului la nivel celular, mareste circulatia sanguina, intareste sistemul imunitar cu efect anti-cancerigen si anti-tumoral.
Anti-Cancerigen, Anti-Tumoral, Imunomodulator
Stimulant pentru: Energia sexuala (virilitate)
Suport pentru: Circulatia Sanguina, Functia hepatica, Functia pulmonara
Energizant activitate intelectuala
Bacteriostatic pentru: Pneumococ, Streptococ, Stafilococ Auriu (Aureus)
Pentru virilitate: 4-5 capsule administrate cu 30 minute-1 ora inainte de actul sexual au ca efect un act sexual dinamic si de durata
Mai concentrata si mai pura decat alte produse similare
*
Suport pentru Functia Hepatica (Ficat) si Sistemul Nervos, Mareste eliberarea de energie la nivel celular, Mareste gradul de utilizare al Oxigenului la nivel celular, Mareste Circulatia Sanguina, Intareste Sistemul Imunitar cu efect Anti-Cancerigen si Anti-Tumoral
*
Supranumita in Medicina Orientala “Leacul Bun pentru Toate”, CORDYCEPS actioneaza in organism la nivele multiple, de la actiuni benefice pentru functia hepatica si sistemul nervos pana la efecte energizante, imunoastimulatoare, imbunatatirea capacitatii de utilizare a oxigenului in celule precum si imbunatatirea circulatiei sanguine.
Ciuperca de larvā chinezeascā, de asemenea cunoscută şi sub numele de Cordyceps Sinensis creste in mlaştina verde a Platoului Tibetan.. Este considerată una dintre cele 3 tonice de vîrf în medicina tradiţională, alături de ginseng şi de ganoderma. Vara seamănă cu un vierme şi iarna cu iarba. De aici şi numele în chineză de “Dongchong Xiacao”, care literalmente înseamnă“Iarna-vierme & Vara-iarbă”.
Doua substantea active au fost identificate in Cordyceps: cordycepin (deoxyadenosine) si acid cordycepic (mannitol).
ACTIUNE:
- Efectiv pentru reglarea imunologica, detine calitati puternice adaptogene (imunomodulator).
- Ca antibiotic natural. Ofera actiune bacteriostatica asupra catorva zeci de bacterii patogene, inclusiv bacterii ca pneumococus, streptococus, stafilococii aurii.
- Poseda actiuni antinflamatorii, actiune analoga cu hormonii. In anumite situatii chiar intrece ca eficacitate hidrocortizonul.
- Asigura dilatarea vaselor sanguine, imbunatatind vascularizarea muschilor inimii si a altor organe.
- Administrata in doza de 2400 mg (4 capsule) conduce la un act sexual mai dinamic (viril)
- Mareste capacitatea organismuli de a utiliza oxigenul, mareste capacitatea de munca, capacitatea functionala si nivelurile energetice ale organismului.
- Scade nivelul lipidelor din sange, inclusiv colesterolul, regleaza echilibrul dintre calciu si fosfor din sange
- Elimina activ din organism substantele toxice inclusiv ale preparatelor medicamentoase
- Imbunatateste functiile ficatului, rinichilor, plamanilor
- Regleaza numarul trombocitelor in sange
- Are actiune anticancerigena datorita imbunatatirii oxigenarii, stimuleaza activitatea leucocitelor, ajuta la eliminarea efectelor secundare ale radioterapiei.
INDICATIILE TERAPEUTICE:
- Boli ale organelor respiratorii : bronsita, pneumonie, astm bronsic, emfizem pulmonar, tuberculoza, etc
- Boli ale aparatului cardiovascular si ale vaselor de singe : ischemie cardiaca, infarctul de miocard, stenocardie,tromboze
- Boli ale cailor urinare: colici renale, urinari dese, polutie (eliminarea spontana a spermei ) glomerulonefrita, cistita, etc
- Tumori maligne ale diferitelor organe, chiar in stadii avansate ( imbunatatirea simtitoare a functiilor organului afectat), contribuie la diminuarea efectelor negative ale chimioterapiei si radioterapiei
- Boli ale ficatului : hepatita, profilaxia cirozei hepatice, imbunatateste schimburile in celulele ficatului ( hepatocistite )
- Boli ale singelui : hemoragii ale mucoaselor, purpura trombocitopenica (boala Verlgof ), anemii, leucoze
- Intoxicatii chimice : ajuta la eliminarea substantelor toxice, toxinelor intestinale, efectelor nocive ale medicamentelor de sinteza,
- Efect curativ si tratament profilactic pentru intarirea imunitatii
- Lipsa de stamina si anduranta sexuala
The Ultimate Anti-aging Mushroom
The Cordyceps mushroom, Cordyceps sinensis, has the reputation of being one of the best anti-aging materials in Traditional Chinese Medicine. Modern research has shown its anti-aging effects on virtually all systems of the human body.
Cordyceps has been used for centuries to protect and enhance sexual, immune, liver, kidney, and heart functions. It is also a great adaptogen for anti-stress support.
CordImmune™ is a revolutionary new product that has all the benefits of the traditional Cordyceps, plus the presence of Cordycepin gives it extra immune support.
CordImmune™ is the only product on the market that contains pure extracts from the Super CS-4 strain of Cordyceps sinensis, a new hybrid strain that is capable of producing high yields of both Adenosine and Cordycepin. Traditionally, Cordycepin has only been found in extracts from Cordyceps millitaris and not in Cordyceps sinensis.
Potential Applications of Cordyceps
- As an anti-aging supplement which improves almost all organ functions and the quality of life.
- Protection of liver and kidney from toxic drugs.
- Sports performance and endurance enhancement.
What is Cordycepin?
Cordycepin is also known as 3’-deoxyadenosine, a nucleoside analog and a transcription chain terminator. When Cordycepin is introduced to cells undergoing DNA replication, it produces a defective DNA that triggers cells to undergo apoptosis (programmed cell death).
Currently, the National Cancer Institute in collaboration with a pharmaceutical company has initiated a Phase I clinical study of Cordycepin as a potential treatment agent.
However, we believe that the whole Cordyceps mushroom would be more potent than a single extract such as Cordycepin alone. We believe that the synergistic effects of Cordyceps polysaccharides, adenosine, cordycepic acid, and cordycepin would be much greater than those achieved by the use of Cordycepin alone.
Research Results
Cordyceps
Following are results of anti-aging studies of Cordyceps on various body systems.
- Cellular ATP: Cordyceps improves sexual function (17) and is traditionally used for fatigue (18).
- Hepatic system (the liver): Cordyceps activates Kupffer cell function, increases SOD and glutathione peroxidase in the liver, raises plasma albumin, and inhibits inflammation and liver fibrosis (1-3).
- Cardiovascular system: Cordyceps inhibits thrombus formation, hypotensive, mildly inhibits platelet aggregation, vasodilation, reduces heart rate, reduces arrhythmia induced by aconitine, and is hypolipidemic (13-16).
- Immune system: Cordyceps modulates cellular immune function, inhibits humoral immune hyperfunction, prevent inhibition of NK cells by cyclophosphamide, protects T helper cells from immunosuppression effects of prednisolone acetate and cyclophosphamide, prolongs allograft survival time, and increases spleen weight (4-6).
- Endocrine system: Cordyceps increases corticosteroid production (differently than ACTH) and stimulates bone marrow hematogenesis function (7-8).
- Malignant cells: Cordyceps inhibits Ehrlich ascites carcinoma, Meth A fibrosarcoma, K562, Jurkat, WM-1342, HL-60, and RPMI-8226 cell lines, and promotes differentiation (9-12).
Cordycepin
Following are results of fundamental studies of Cordycepin.
- Anti-viral: Inhibits the replication of western equine encephalitis virus (19), herpes simplex virus (20, 29), and influenza virus (26).
- Anti-bacterial: Inhibits growth of Clostridium spp. without adverse effects on the growth of Bifidobacterium spp.(21).
- Anti-fungal: Inhibits Candida albicans and Candida krusei (24).
- Immune-regulatory: Up-regulates Interleukin-10 production and inhibits Interleukin-2 production (22).
- Apoptotic: Induces apoptosis in ADA-inhibited TdT-positive leukemia cells (23, 25).
- Radiation damage enhancement: Inhibits the repair of X-ray induced DNA damage (27, 28, 30, 31.
Main Ingredients of Cordyceps
The Cordyceps mushroom is comprised of polysaccharides, adenosine, adenine, uracil, guanine, thymin deoxyriboside, uracil deoxyriboside, 18 different amino acids (including 8 essential ones), polypeptides, mannitol, protein, organic acids, different micronutrients (P, Se, K, Ca, Mg, Mn, Fe, Na, Cu, Zn, Al, Si, Cr, V, Ni, Sr, Ti, and Mo), vitamins (B1, B2, B12, E, and K), ergosterol, superoxide dismutase (SOD), etc.
Dosage
1 to 3 grams per day for maintenance; 3 to 6 grams per day for optimal effects.
Toxicity
A 3-month, placebo-controlled, sub-acute toxicity study in both sexes of rats found the CS-4 strain caused no toxicity or death at a dosage of 3 g/kg orally. A 30-day, placebo-controlled toxicity study in mice found no signs of toxicity and no deaths from CS-4. In both studies, organ weights and peripheral blood cells were not significantly different from those of the controls.
Cordyceps References
- Nakamura K, Yamaguchi Y, Kagota S, et al. 1999. Activation of in vivo Kupffer cell function by oral administration of Cordyceps sinensis in rats. Jpn. J. Pharmacol. 79: 505-508
- Liu P, Zhu J, Huang Y, Liu C. 1996. Influence of Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL-1, IFN, and TNF produced by rat Kupffer. China J. Chin. Materia Medica. 21: 367-69.
- Zhu JL, Liu C. 1992. Modulating effects of extractum semen Persicae and cultivated Cordyceps hyphae on immuno-dysfunction of in-patients with post-hepatitis cirrhosis. Chung-Kuo Chung His I Chieh Ho Tsa Chih. 12:207-09.
- Chen GZ, Chen GL, Sun T, Hsieh GC, Henshall JM. 1991. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin. Med. J. 104:4-8.
- Zhu XY, Yu HY. 1990. Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response. Chin. J. Modern Developments Traditional Med. 10: 485-87.
- Zhang Z, Xia SS. 1990. Cordyceps sinensis-I as an immunosuppressant in heterotopic allograft model in rats. J. Tongji Med. Univ. 10:100-103.
- Chen DM. 1987. Platelet hemopoiesis and ultrastructure observations in mice treated with natural Cordyceps sinensis and its cultured mycelia. Bull. Chin. Materia Medica. 12: 47-49.
- Li Y, Chen GZ, Jiang DZ. 1993. Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow. Chin. Med. J. 106: 313-16.
- Yoshida J, Takamura S, Yamaguchi N, et al. 1989. Antitumor activity of an extract of Cordyceps sinensis (Berk.) Sacc. against murine tumor cell lines. Jpn. J. Exp. Med. 15: 157-161.
10. Kuo YC, Lin CY, Tsai WJ, et al. 1994. Growth inhibitors against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides. Cancer Invest. 12:611-615.
11. Nakamura K, Yamaguchi Y, et al. 1999. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn. J. Pharmacol 79: 335-341.
12. Zhao DH, Lin LZ. 1995. Effect of Jinshuibao capsules on the immunological function of 36 patients with advanced cancer. Chung-Kuo Chung His I Chieh Ho Tsa Chih. 15:476-78.
13. Feng MG, Zhao QG, Feng GH. 1987. Vasodilating effect of cultured Cordyceps sinensis (Berk.) Sacc. mycelia in anesthetized dogs. Bull. Chin. Materia Medica. 12: 41-45.
14. Ikumoto T, Sasaki S, Namba H, et al. 1991. Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria. J. Pharm. Soc. Jpn. 111: 504-509.
15. Zhao Y. 1991. Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits. Chin. Med. J. 71: 612-615.
16. Mei QB, Tao JY, et al. 1989. Anti-arrhythmic effects of Cordyceps sinensis (Berk.) Sacc. China J. Chin. Materia Medica. 14: 616-618
17. Yang WZ, Deng Xa, Hu W. 1985. Treatment of sexual hypofunction with Cordyceps sinensis. Jiangxi Zhongyiyao. 5: 46-47.
18. Manabe N, Sugimoto M, et al. 1996. Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. Jpn. J. Pharmacol. 70:85-88.
Cordycepin References
19. Hashimoto K, Simizu B. 1976. Effects of Cordycepin on the eplication of Western Equine Encephalitis virus. Arch. Virol. 52(4): 341-5.
20. de Julian-Ortiz JV, Galvez J, et al. 1999. Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. J Med Chem. 42(17): 3308-14.
21. Ahn YJ, Park SJ, et al. 2000. Cordycepin: Selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. J Agric Food Chem. 48(7): 2744-8.
22. Zhou X, Meyer CU, et al. 2002. Effects of Cordycepin on interleukin-10 production of human peripheral blood mononuclear cells. Eur J Pharmacol. 453(2-3): 309-17.
23. Koc Y, Urbano AG, et al. 1996. Induction of apoptosis by Cordycepin in ADA-inhibited Tdt-positive leukemia cells. Leukemia. 10(6): 1019-24.
24. Sugar A, McCaffrey R. 1998. Antifungal activity of 3’-deoxyadenosine (cordycepin). Antimicrob Agents Chemother. 42(6): 1424-27.
25. Kodama EN, McCaffery RP, et al. 2000. Antileukemic activity and mechanism of action of Cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. 59(3): 273-81.
26. Hahy BW, Cox NJ, et al. 1973. Multiplication of influenza virus in the presence of Cordycepin, an inhibitor of cellular RNA synthesis. 243(127): 172-4.
27. Robertson JB, Williams JR, Little JB. 1978. Enhancement of radiation killing of cultured mammalian cells by Cordycepin. Int J Radiat Biol Relat Stud Phys Chem Med. 34(5): 417-29.
28. Hiraoka W, Tanabe K, et al. Metabolic effects of 3’-deoxyadenosine (cordycepin) and 2-halo 3’-deoxyadenosine on repair of X-ray induced potentially lethal damage in Chinese hamster V79 cells. Radiat Res. 114(2): 231-9.
29. Becker Y, Olshevsky U. 1973. Inhibition of Herpes simplex virus replication by Cordycepin. Isr J Med Sci. 9(11): 1581-5.
30. Hiraoka W, Kuwabara M, Sato F. 1990. Effects of 3’-deoxyadenosine (cordycepin) on the repair of X-ray induced DNA single- and double-strand breaks in Chinese hamster V79 cells. J Radiat Res (Tokyo). 31(2): 156-61.
31. Yokoiyama A, Kada T, Kuroda Y. 1992. An inhibitor of potentially lethal damage (PLD) repair reduces the frequency of gamma-ray-induced mutation in cultured Chinese hamster V79 cells. Mutat Res. 268(2): 247-54.
Cordycepin
From Wikipedia, the free encyclopedia
Jump to: navigation, search
|
Cordycepin |
|
| IUPAC name | [show]
9-(3-Deoxy-β-D-ribofuranosyl)adenine |
| Other names | Cordycepine 3′-Deoxyadenosine |
|
Identifiers |
|
| CAS number | [73-03-3] |
| SMILES | [show]
O[C@@H]1C[C@@H](CO)O[C@H]1N2C(N=CN=C3N)=C3N=C2 |
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Properties |
|
| Molecular formula | C10H13N5O3 |
| Molar mass | 251.24 g/mol |
| Melting point | 225.5 °C, 499 K, 438 °F |
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Except where noted otherwise, data are given for |
|
Cordycepin, or 3′-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of oxygen in the 3′ position of its ribose part. It was initially extracted from fungi of genus Cordyceps, but is now produced synthetically.
Because cordycepin is similar to adenosine, some enzymes cannot discriminate between the two. Therefore, it can participate in certain biochemical reactions (for example, be incorporated into an RNA molecule, thus causing the premature termination of its synthesis).[1]
See also
- Deoxyadenosine
References
- ^ “The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin“. J. Cell Biol. 41: 510 -520. 1969. http://www.jcb.org/cgi/reprint/41/2/510.
Retrieved from “http://en.wikipedia.org/wiki/Cordycepin”
Cordycepin
Synonyms: 3′-Deoxyadenosine; 9-Cordyceposidoadenine; Cordycepine;ADENOSINE,3′-DEOXY-;
9H-Purine, 6-amino-9-(3-deoxy-beta-D-ribofuranosyl)-; 9-(beta-D-3′-Deoxyribofuranosyl)adenine
CAS No.: 73-03-0
Mol. Formula: C10H13N5O3
Mol. Weight: 251.24
Botanical Source: Cordyceps.
Catalogue No.: C08055
Purity: > 98% 99% by HPLC
Packaging: 20mg, 50mg,100mg,1g,10g,100g…
Package and quantity according to customer’s detail requirement.
Remark: In stock, customized for large scale.
Cordycepin is a derivative of adenosine, differing by the absence of oxygen in the 3′ position of its ribose part. It is extracted from fungi of Cordyceps.
Cordycepin is the main functional component in Cordyceps, one of the top three famous traditional Chinese medicine. It was reported to have wide range functions, such as enhancing body’s immune function, anti-aging, anti-fatigue, anti-cancer, anti-bacterial and anti-virus, androgen function, hypolipidemic and hypoglycemic effects. US national Cancer Institute defines it as an anticancer drug that belongs to a family of drugs called antitumor antibiotics. It has been used in various health products worldwide.
Cordycepin, being similar to adenosine, can be incorporated into RNA and causes premature termination of its synthesis. Cordycepin and Cordycepin triphosphate have been used extensively in the study of gene/mRNA transcription.
References
1,Growth Inhibitors Against Tumor Cells in Cordyceps sinensis Other than Cordycepin and Polysaccharides
Cancer Investigation, Volume 12, Issue 6 1994 , pages 611 – 615
2,Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin
Proceedings of the National Academy of Sciences December 1, 1970 vol. 67 no. 4 1878-1885
3,Measurement of cordycepin and adenosine in stroma of Cordyceps sp. by capillary zone electrophoresis (CZE)
Journal of Bioscience and Bioengineering Volume 94, Issue 4, October 2002, Pages 371-374
4,The Effects of Benzyladenine, Cycloheximide, and Cordycepin on Wilting-Induced Abscisic Acid and Proline Accumulations and Abscisic Acid- and Salt-Induced Proline Accumulation in Barley Leaves
Plant Physiology 82:703-707 (1986)
